研究兴趣：我们的科研工作处于生命科学、物质科学及计算科学的交叉领域。利用前沿的多维核磁共振波谱学技术、计算机模拟等多种实验和理论方法定量研究核酸、蛋白质等大分子的空间三维结构，并且探测这些结构随着时间（皮秒至秒的时间尺度）的动态变化过程。我们工作中所获取的生物大分子结构和构象动态信息对于理解生物分子行使其生理功能的机制机理以及针对生物大分子的药物研发都意义重大。
2005年毕业于武汉大学获得理学学士学位 2010年毕业于新加坡国立大学获得博士学位（导师：杨代文）
2010-2012，美国国家强磁场实验室/佛罗里达州立大学，博士后（导师：rafael brüschweiler） 2012-2015，加拿大多伦多大学，博士后（导师：lewis e. kay, frs, nas member） 2015至今，中国科学技术大学，教授、博士生导师
1. | 基金委优秀青年科学基金项目 | 2. | 国家自然科学基金面上项目 |
d. liu, x. chen, and d. long*, nmr-derived conformational ensemble of state 1 of activated ras reveals insights into a druggable pocket, j. phys. chem. lett. 11, 3642-3646 (2020). x. chen, h. yao, h. wang, y. mao, d. liu, d. long*, extending the lifetime of native gtp-bound ras for site-resolved nmr measurements: quantifying the allosteric dynamics. angew. chem. int. ed. 58, 2730-2733 (2019). p. cheng, d. liu, p. x. chee, d. yang, d. long*, atomistic insights into the functional instability of the second helix of fatty acid binding protein. biophys. j. 117, 239-246 (2019). h. wang, s. wang, c. li, h. li, y. mao, w. liu, c. xu*, d. long*, probing transient release of membrane-sequestered tyrosine-based signaling motif by solution nmr spectroscopy. j. phys. chem. lett. 8, 3765-3769 (2017). y. mao, h. yao, h. wang, p. cheng, d. long*, microsecond timescale dynamics of gdp-bound ras underlies the formation of novel inhibitor-binding pockets. angew. chem. int. ed. 55, 15629-15632 (2016). d. long*, f. delaglio, a. sekhar, l. e. kay*, probing invisible, excited protein states by non-uniformly sampled pseudo-4d cest spectroscopy. angew. chem. int. ed. 54, 10507-10511 (2015). d. long, g. bouvignies, l. e. kay, measuring hydrogen exchange rates in invisible protein excited states. proc. natl. acad. sci. u.s.a. 111, 8820-8825 (2014). d. long, c. b. marshall, g. bouvignies, m. t. mazhab-jafari, m. j. smith, m. ikura, l. e. kay. a comparative cest nmr study of slow conformational dynamics of small gtpases complexed with gtp and gtp analogues. angew. chem. int. ed. 52, 10771-10774 (2013). d. long, r. brüschweiler. directional selection precedes conformational selection in ubiquitin-uim binding. angew. chem. int. ed. 52, 3709-3711 (2013). d. long, r. brüschweiler. atomistic kinetic model for population shift and allostery in biomolecules. j. am. chem. soc. 133, 18999-19005 (2011).
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